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In the most comprehensive pediatric meta-analysis, Contopoulos-Ioannidis et al., ( Age-specific extended-interval protocols account for developmental pharmacokinetic variability, particularly the maturational changes in GFR and volume of distribution that influence aminoglycoside clearance across gestational and postnatal age

Lee AC, Fenster BE, Ito H, Takeda K, Bae NS, Hirai T, Yu ZX, Ferrans VJ, Howard BH, Finkel T (1999) Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

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Among these, 38 are known secreted proteins (70.4%) and 37 were previously reported as itaconated (68.5%), mirroring the specificity we observed in Raw264.7 cells (Supplementary Fig