glutathione and glutamate cysteine liaase

glutathione and glutamate cysteine liaase Frontiers Non-canonical Glutamate-Cysteine Ligase Activity Protects

Name: glutathione and glutamate cysteine liaase Frontiers Non-canonical Glutamate-Cysteine Ligase Activity Protects
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Non canonical Glutamate Cysteine Ligase Activity Protects against Ferroptosis ScienceDirect Glutamate Cysteine Ligase an overview ScienceDirect Topics Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis bioRxiv Clinical and molecular characterization of 6 children with glutamate cysteine ligase deficiency causing hemolytic anemia ScienceDirect

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Dai E, Zhang W, Cong D, Kang R, Wang J, Tang D

Glutathione (GSH) Key Research Facts Chemical identity: Tripeptide gamma-glutamyl-cysteinyl-glycine (Glu-Cys-Gly) Molecular weight: 307.32 Da (reduced form, GSH) Cellular concentration: 110 mM in cytosol

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On the basis of these observations, and as suggested by our model in which HPV-16 E7 occupies the space between Cys 47 and Cys 101 of GSTP1 and prevents both intramolecular and intermolecular disulfide formation, we propose that HPV-16 E7 binding might protect GSTP1 against inactivation via oxidative attacks at Cys 47 and/or Cys 101