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It can be prevented by GPX4-mediated detoxification of lipid peroxides [6,7,8,9] or by limiting cellular iron availability [10,11,12,13,14] (Fig

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Cobalamin conversion 10 M MeCbl was preincubated with 0.4 M recombinant human His-sumo-GSDME for 30 min, the complex was then illuminated with 60 W bulb with 1520 cm distance overnight to convert MeCbl to HOCbl