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Notably, SOD1 induced an increase in [Ca 2+ ] i by intracellular and extracellular dependent mechanisms

In diabetic wounds, hyperglycemia, chronic inflammation, and other pathological factors impair the activity of these enzymes, limiting ROS scavenging

Commenters supported what they described as CMS's efforts to ensure that the medically necessary standard keeps up with growing clinical evidence and evolving standards of care