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4 Conclusion and future perspectives The mechanisms of cell death, encompassing over 20 distinct forms including apoptosis, autophagic cell death, lysosomal-dependent death, paraptosis, pyroptosis, NETosis, necroptosis, and immunogenic cell death, have unveiled revolutionary avenues for cancer therapeutics (Figure 12)

Therefore, manipulating MSCs in various ways is crucial to overcome this obstacles, bringing the clinical application of MSCs closer to reality, particularly in the treatment of PD as a growing neurodegenerative condition that impose a significant burden on both patients and also society