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Although effective in treating other varieties of BRAF V600E malignancies, tolerance towards BRAFi as a monotherapy has been shown in melanoma and HGG, commonly through (acquired, secondary) reactivation of the MEK pathway in melanoma, and resistance mechanisms are discussed in more detail below

In addition, ongoing studies aim to clear up its actions

[DOI] [PMC free article] [PubMed] [Google Scholar] Meyer NA, Barrow RE, Herndon DN

However, it is important to note that approximately 80% of patients will experience a relapse, ultimately leading to disease progression and mortality [6]