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Within these motifs, some sequences showed alterations, such as: in GPX2 homolog of V

ICS, inhaled corticosteroid

Abbreviations AcAc: Acetoacetate acetyl-CoA: Acetyl coenzyme A AD: Alzheimers disease ALS: Amyotrophic lateral sclerosis AMPK: AMP-activated protein kinase APP: Amyloid precursor protein ATP: Adenosine triphosphate A: -Amyloid Bcl-2: B-cell lymphoma 2 BDNF: Brain-derived neurotrophic factor BHB: -Hydroxybutyrate C9orf72: Chromosome 9 open reading frame 72 COX-2: Cyclooxygenase-2 D-BHB: D--Hydroxybutyrate EAE: Autoimmune encephalomyelitis HCA2: Hydroxycarboxylic acid receptor 2 HD: Huntingtons disease HMG-CoA: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA HTT: Huntingtin ILs: Interleukins KD: Ketogenic diet LPS: Lipopolysaccharides MCT: Medium-chain triglyceride MS: Multiple sclerosis mTORC1: Mammalian target of rapamycin complex 1 NADH: Nicotinamide adenine dinucleotide hydrogen NF-B: Nuclear factor kappa B NLRP3: Nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing protein 3 NMDA: N -Methyl-D-aspartate Nrf2: Nuclear factor erythroid 2-related factor 2 PD: Parkinsons disease PGC-1: Peroxisome proliferator-activated receptor coactivator 1- ROS: Reactive oxygen species SCFAs: Short-chain fatty acids SIRT1: Sirtuin-1 SOD1: Superoxide dismutase 1 TCA: Tricarboxylic acid TNF-: Necrosis factor-alpha References Dugger BN, Dickson DW