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In deuterostomians, apart from the substrate conversion role in the VC synthesis pathway, Regucalcin is also implicated in several physiological mechanisms, such as intracellular Ca 2+ homeostasis, proteolysis, and signaling and oxidative stress regulation [23]

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In the latter studies, patients were receiving neuroleptic treatment and some of the variability of the results may therefore be related to medication status (drug-nave versus patients on medication), sample source, ethnicity or the region of the brain investigated

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