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Neovascularization involves several growth factors and cytokines, such as fibroblast growth factor (FGF), platelet-derived endothelial cell growth factor (PD-ECGF), angiopoietin (Ang)1/2, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), among which vascular endothelial growth factor (VEGF) is the most vital irritant

Conversely, such combinations may lessen the need for strict dietary adherence to achieve benefits, thereby improving clinical feasibility and patient adherence

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As can promote the initiation and development of the tumor by epigenetic changes of critical oncogenes or tumor suppressors as gene promoters