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Statements Author contributions All authors listed, have made substantial, direct and intellectual contribution to the work, and approved it for publication

Meanwhile, Acyl-coA synthetase long-chain family member 4 (ACSL4) esterifies PUFAs into phospholipids, expanding the pool of oxidizable substrates, while the 15-lipoxygenase(15-LOX)/phosphatidylethanolamine-binding protein 1 (PEBP1) complex catalyzes the formation of specific peroxidized PE species, serving as a persistent source of ROS [145]

There is some evidence that liposomal glutathione can help protect the body from alcohol damage

Conclusion and perspective In summary, DNA methylation, histone modification, m6A modification and other epigenetic modifications play a role in regulating different death modes of tumor cells, such as pyroptosis, ferroptosis and cuproptosis