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Hepatic copper accumulation induces DNA strand breaks in the liver cells of Long-Evans Cinnamon strain rats

In a phase I trial (NCT01800812) with solid tumor patients, OM-174 as a monotherapy was well tolerated and proved to be effective for the induction of IL-8, IL-10, TNF-, and IL-6 (despite that TNF-and IL-6 decreased progressively in repeated treatment)