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With regard to distribution , for drugs such as diazepam 1 and penfluridol 5 that are substantially distributed into adipose tissue, greater adiposity is associated with greater storage of the drug in lipid reservoirs, and hence greater availability of the drug for return to blood as blood levels fall due to metabolism

1 H NMR (400 MHz, DMSO-d 6 ) 9.45 (br, 1H), 8.87 (br, 1H), 8.34 (d, J=9.2 Hz, 1H), 8.01 (d, J=8.8 Hz, 1H), 7.98 (d, J=8.8 Hz, 1H), 7.87 (dd, J=8.4, 7.6 Hz, 1H), 7.57 (dd, J=7.6, 7.6 Hz, 1H), 7.17 (d, J=9.2 Hz, 1H), 3.87 (s, 3H)

The British National Formulary (BNF) provides full clinical information on hydroxocobalamin

Detection and in vitro metabolism of AOD9604 Drug Test Anal, 2015, PMID 41490200 Rahman OF, Lee SJ, Seeds WA