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When they become active, cell death is essentially inevitable

However, major expert groups have looked at the research and concluded that: The evidence is not sufficient to show that screening every adult without symptoms for vitamin D deficiency clearly improves outcomes such as fractures, heart disease or cancer

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Among these patients, 3 experienced disease progression (PD) during the first treatment cycle, 2 had stable disease, and 2 developed PD after having achieved response (1 partial response [PR] and 1 very good partial response [VGPR]) ( Supplementary Figure S1 )