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A senolytic is a compound that selectively targets and eliminates senescent (growth-arrested) cells while sparing normal, proliferating cells

RIPK3-mediated inflammation is a conserved cell response to ER stress

[PMID:29927703] Pilkington M, Harbaugh CM, Hirschl RB, et al

Everything needs to be in balance.[ref][ref] Prostate cancer risk is increased with 4-HOE1(E2) metabolites also.[ref] In general, the estrogen metabolites that start with 2 are good, and the ones that start with 4 or 16 need to be limited or at least eliminated quickly from the body.[ref] Here is a diagram of how these metabolites go together: As you can see, upregulating the CYP1A1 enzyme is going to increase the 2-OHE1 path