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James E, Vielle A, Cusato K, Li H, Lee B, Parween S, et al

While NAD therapy shows promise in several areas, we emphasize that more clinical research is needed to fully understand its benefits, risks, and best practices

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2.1.1.1 All- trans retinoic acid (ATRA) CD38 expression can be modulated both in vitro and in vivo through the nuclear retinoic acid receptor ( in vivo use, has proven effective in enhancing CD38 levels in several ex vivo myeloma cell preparations, leading to improved efficacy of therapeutic antibodies ( in vivo efficacy in combination with Daratumumab was called into question in a clinical trial involving relapsed/refractory (RR) MM patients