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doi: 10.3389/fcell.2018.00090 Received 31 May 2018 Accepted 25 July 2018 Published 15 August 2018 Volume 6 - 2018 Edited by Concetta Bubici, Brunel University London, United Kingdom Reviewed by Alice Newman, University of Glasgow, United Kingdom

While this reaction was traditionally viewed as a minor nicotinamide clearance pathway, research has revealed that NNMT activity has far-reaching consequences for cellular metabolism through multiple interconnected mechanisms