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Proc Natl Acad Sci USA 1985

Today 53, 240-253 (2018)

The other historical doses (1 mg, 4 mg, 8 mg) remain Phase 2 / research reference points only

Vitamin B12 is essential for neurologic function, red blood cell creation, and DNA synthesis and is a coenzyme for three primary biochemical conversions: homocysteine to methionine, 5-methyltetrahydrofolate to tetrahydrofolate, and methylmalonic acid to succinyl coenzyme A [1, 2]