lipid peroxidation hepatitis c virus+ drug resistance PEMT Mediates Virus-Induced Steatosis, Explains Genotype-Specific Phenotypes and Supports Virus Replication High levels of fatty acids

10.1093/pcp/pcx180

Mol Cell Biol 24:94149423 Matsushima S, Ide T, Yamato M, Matsusaka H, Hattori F, Ikeuchi M, Kubota T, Sunagawa K, Hasegawa Y, Kurihara T, Oikawa S, Kinugawa S, Tsutsui H (2006) Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice

Moreover, p53 can increase the expression of spermine/spermine N1 acetyltransferase 1 (SAT1) and glutaminase 2 (GLS2), making cells more sensitive to ferroptosis, or promote ferroptosis by transcriptionally upregulating mitochondrial GLS2 [29]

58 Similarly, alcoholic liver injury does not develop in mice that lack the TNF type I receptor