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2.13.1.5 V717I (London mutation) Position 717 in the amyloid precursor protein (APP) is a well-established hotspot for mutations linked to autosomal dominant Alzheimers disease (ADAD)

In a fifth aspect, the invention relates to a pharmaceutical composition, hereinafter pharmaceutical composition of the invention, comprising fingolimod, an analogue, metabolite or derivative thereof or a pharmaceutically acceptable salt, and one or more drugs selected from the group consisting of an antioxidant, an antioxidant targeted to mitochondria, a histone deacetylase inhibitor, an inhibitor of mitochondria transition pore opening, an anti-inflammatory drug, a PPAR agonist, a RXR agonist, asirtuin1 agonist, an hypolipidemic drug and an autophagy activator

However, unlike most RTAs that inhibit ferroptosis, such as -tocopherol, Lip-1 does not follow the general trend of many ferroptosis suppressors, whereby RTA activity is closely correlated with ferroptosis inhibition 23

The in-hospital death model had moderate-good risk discrimination (C=0.70)