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The 2021 European Group on Graves Orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves orbitopathy

NTS were motile yet severely disrupted in morphology

The core issue copper overload remains unaddressed

By adopting the reverse translation of validated circuitry- relevant human endpoints approach [2], we provide convincing proof-of-concept for targeting OxS through antioxidant-based strategies in individuals with schizophrenia and underscore the importance of breaking the various vicious circles associated with OxS as means to prevent the propagation of processes that may precede the onset of disease