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25 More recent studies have also linked vitamin D deficiency to sickle cell disease, aromatase inhibitorinduced arthralgia, headache, PHN, pain in patients taking high doses of opioids, and various types of musculoskeletal and orthopedic pain

In some embodiments, one or more of the compounds 101-105 have a synergistic effect with one or more of the above umami flavor compounds or combinations of umami flavor enhancing compounds

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Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease