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The TRIUMPH-4 trial showed that retatrutide at 12mg reduced: Systolic blood pressure: 14.0 mmHg reduction Non-HDL cholesterol: clinically meaningful improvement High-sensitivity C-reactive protein: significant reduction (a marker of systemic inflammation) Triglycerides: substantial decrease Tirzepatide produces similar cardiovascular improvements, with well-documented reductions in blood pressure, triglycerides, and inflammatory markers across the SURMOUNT and SURPASS programs

Mycotaxon 91, 6173 (2005)

This study aimed to characterize a diverse urban DM population, calculate FIB-4 scores, identify factors associated with FIB-42.67, and determine cost implications of algorithm adherence

However, further studies are needed to confirm these effects in the -cells