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To this end, we first assessed the effect of OLFM4 as a whole (both intracellular and secreted forms) on GC growth and found that knockdown of OLFM4 significantly decreased the colony and sphere formation of HGC-27 and AGS cells (Supplementary Fig

When we took an in-depth examination of the KEGG hsa00982 pathway, we found that CYP2D6 was associated with the metabolic process of psychiatric drugs: tamoxifen, codeine, and citalopram (Figs

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Unlike mitochondrial ROS, which are produced as metabolic byproducts, NOX enzymes generate ROS in a tightly regulated and deliberate manner as part of redox signaling networks (Magnani and Mattevi, 2019