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The differential diagnosis of thyroid nodules is now easily accomplished by fine needle aspiration cytology in 60-90% of the cases, allowing a significant reduction in the number of thyroid surgeries performed for thyroid nodules

The increased expression of one of the enzymes involved in the non-oxidative pathway, TKTL1, was associated with the poor prognosis of colon and urothelial cancers (Langbein et al., 2006), suggesting that the non-oxidative arm is also critical for the malignant growth of some cancers

Others begin both simultaneously, accepting slightly more complexity in exchange for earlier combined benefits

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