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SharmaHEl RassiGDLathropADobrevaVBBelemTSRamanathanR

doi: 10.1155/2019/5678548

The accumulation of excessive ROS can induce cellular damage (6062), impairing tissues and organs normal functioning

ROS plays a mediator role of pivotal functions such as phagocytosis, antigen presentation and recognition, cytolysis and phenotypical differentiation in immune cells ( + T cells and ROS may promote the expression of forkhead box protein 3 (FOXP3) in Tregs and maintain the immunosuppressive function ( In this review, we summarize several mechanisms by which RT induces ROS production and OS in tumors