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Nevertheless, high viscosity cervical mucus provides less opportunity for transport of pathogens harboring antimicrobial resistance genes and therefore mucus permeability and the stage of the menstrual cycle influence an individuals risk of developing resistant gynecological infections

The transmembrane rather than paracellular transport of lipophilic compounds was supported by the demonstration of an inverse association between lipid/water partition coefficient and increased transport rate following calcium chelation, i.e., disrupting intercellular junctions increased the transport of hydrophilic but not of lipophilic small organic molecules [31]

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To test this, we first analyzed the ubiquitin chain linkage preference of OTUD5 DUB activity