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Second, safety concerns arise because nanocarriers, while enhancing therapeutic effects by improving permeability, also increase the risk of cytotoxicity and potential harm to the nervous system

10.3389/fnagi.2020.00262 88 ZhaoL.LiJ.SuY.YangL.ChenL.QiangL.et al (2020)

Beef, fish, eggs, and dairy all contain naturally high amounts of B12

In addition, the following studies were excluded: in vitro , in vivo , ex vivo studies, case reports, observational studies (cross-sectional, casecontrol, cohort) and quasi-experimental studies