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Here too, there are many indications that it is not the B12 concentration in the blood that is decisive, but that in the cerebrospinal fluid, as has already been discussed above in relation to schizophrenia (32)

The decision of when to start B12 injections is individual and depends on factors like the severity of the deficiency, the underlying cause, and the patients health status

Indeed, recent studies showed that, in addition to mediating ADCC in in vitro and ex vivo models, isatuximab and daratumumab directly activated NK cells and increased their lytic activity against tumor cells through CD16 and CD38 crosslinking [32, 33]

SC, IM, IP, and oral routes are all used in the published literature, with SC and IM most common