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The most common method, also introduced by Schilling, is to inject a high dose of unlabeled B12 to saturate all binding capacities of the B12 binding proteins, and thereby facilitating urinary excretion of the absorbed radioactively labeled B12

The satellite cell activation potentially adds nuclei to muscle fibers, which remain even after stopping DES

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Whilst some patients would prefer injections to skin patches or nasal sprays to sub-lingual tablets or sprays others might, and this already happens in a few cases, they might prefer daily oral tablets