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Using metabolomic analysis, the discrepancies observed between the lipid profiles of keratinocytes after UVB exposure were found to originate mainly from oxidized PE, and the accumulation of the oxidized PE is believed to be essential for executing keratinocyte ferroptotic cell death after UVB radiation

Activation of Akt/Wnt/-catenin signal transduction by CXXL12/CXCR4 induces the expression of VE-cadherin and stabilizes its interaction with VE-cadherin-associated phosphatases to maintain the integrity of endothelial cells and favours a contractile phenotype over a synthetic phenotype in arterial SMCs, thus inhibiting atherosclerosis

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For patients receiving intramuscular hydroxocobalamin, routine rechecking of serum B12 levels is not usually necessary