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Exclusion criteria consisted of research falling outside the specified time, topics beyond the scope of this review, and unpublished studies, books, conference proceedings, abstracts, and dissertations

Faour O., Gilloteaux J

the catalytic core domain contains a trio of amino acids that coordinate binding with a divalent metal cofactor (either Mg2 + or Mn2 + ), and this region forms the active catalytic site (Figure 10).[37,38,39]