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Safe Supplementation: Balancing B12 Intake To ensure safe supplementation: Consult your doctor before starting any B12 supplement regimen Follow recommended dosages Be aware of potential interactions with medications Consider dietary sources of B12 (meat, fish, dairy, fortified cereals) Remember, most people can obtain the recommended 2.4 mcg of B12 through their daily diet

Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport

The patients at highest risk were those on higher doses, those with pre-existing borderline B12 levels, those with a history of metformin use (which independently depletes B12), and those over age 60

As a watersoluble nutrient, the body typically eliminates excess B12, and there is currently no established upper intake limit for healthy individuals