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Inactive Ang I is then converted into Angiotensin II (Ang II) via the cleavage of two amino acids from the C-terminal by ACE1 at the endothelium

doi: 10.1046/j.1462-5822.2003.00257.x 203 MazerB.DomenicoJ.SawamiH.GelfandE

A small-molecule antagonist of HIF2alpha Is efficacious in preclinical models of renal cell carcinoma