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While the Akt/eNOS, NOX and Nrf2 pathways have been widely studied in the literature, it has been shown that phenolic compounds can modulate various cellular functions indirectly related to the redox balance regulation, such as inflammation or endothelial dysfunction (Reference Ruskovska, Maksimova and Milenkovic71)

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The protein level of significantly increased p16 was confirmed in keloid lesions and fibroblasts based on western blot analysis ( p = 0.0007, p = 0.03

If you are on metformin, or choose to take it, please be sure to assess B12 regularly