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Results Effect of colistin on mitochondrial membrane potential and oxygen consumption rate in freshly isolated mitochondria To assess the mitochondrial toxicity of colistin, freshly isolated mitochondria were incubated for one hour with 1 M colistin, and then the quenching of the Rho123 fluorescent signal was monitored over time

The possible transport mechanisms together with the wide tissue distribution underlie the role of OCTN2 as the major transporter responsible for the traffic of carnitine and carnitine derivatives in the intestine, distribution to several body districts and reabsorption/excretion in the kidney (Figure 2)

Examples of aromatic heterocyclyl groups are pyridine, pyrrole, furan, thiophene, benzofuran, imidazoline, quinolen, quinoline, pyridazine and naphthyridine

The kidneys also eliminate excess carnitine through urine to maintain healthful concentrations