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Asymmetric dimethylarginine (ADMA), a recognized NOS endogenous competitive inhibitor, also plays a role in the pathogenesis of lowering NO generation in several disorders [63]

In aggregate, these findings depict an altered metabolic environment in BWS hepatocytes, with increased breakdown of lipids for downstream metabolic processes

doi: 10.1002/advs.202004433 9 NeurathMF

Glutathione IV is paired with chemical peels (glycolic or TCA), low-fluence Q-switched Nd:YAG laser toning, medical-grade topical regimens (vitamin C, niacinamide, tretinoin) and tranexamic acid where indicated