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The detection of IDH1 mutations in EV-derived DNA from plasma and CSF provides a minimally invasive alternative to conventional tissue biopsies, enabling a comprehensive molecular assessment of GBM

Journal of Psychopharmacology

Group 5 Immunized control, Group 6 Immunized folate deficient, Group 7 Immunized control + aspartame, Group 8 Immunized folate deficient + aspartame

The selection advantage of clones is conferred by somatic genetic lesions described as driver mutations [134], and the initial mutation takes place in HSCs with self-renewal capability