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Recent studies have linked low DNMT1 expression with TMZ resistance, suggesting that alterations in DNA methylation may serve as indicators of treatment efficacy

Buonfiglio, F., Bhm, E

Again, this is in patients who had not previously responded to numerous medications

You should always discuss treatment with your transplant consultant, but they might not give a DLI for reasons such as: When a second transplant is the best treatment option Doctors will only consider a second transplant in the case of relapse or graft failure