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The inhibition of chemerin increases intracellular PUFA levels and decreases MUFA levels, leading to impaired mitochondrial respiratory chain function and CoQ10 and CIV down-regulation, resulting in more ROS generation and the induction of iron-mediated cell death (85)

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Inhibiting ferroptosis alleviated Crizotinib-induced hepatotoxicity To elucidate the specific cell death pathways induced by Crizotinib in hepatocytes, Crizotinib was combined with various cell death inhibitors in AML12 cells