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As expected, salsolinol formation was catalase-dependent, as lowering the units/mL of the enzyme also reduced salsolinol abundance (Supplementary Fig

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With regards to their use as penetration enhancers in some embodiments, chelating agents have the added advantage of also serving as DNase inhibitors, as most characterized DNA nucleases require a divalent metal ion for catalysis and are thus inhibited by chelating agents (Jarrett, J