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Similarly, certain anticonvulsants, particularly phenytoin and phenobarbital, may alter B12 metabolism and could theoretically affect the therapeutic response to methylcobalamin supplementation

Collectively, these changes translate into a more pronounced improvement in mucosal barrier repair than that achieved with 5-ASA alone ( The combination of natural bioactive compounds with 5-ASA offers a novel therapeutic strategy for ulcerative colitis through a stage-specific, multi-target synergistic approach.These complementary mechanismsspanning acute immunomodulation, antioxidative damage, followed by active mucosal repair, and microbiota-metabolic regulationare visually integrated in Figure 2, which provides a comprehensive overview of their temporally coordinated actions

Antioxidants are substances that can eliminate and neutralize FRs within the body and free the body from the oxidative stress that occurs due to the accumulation of FRs

10.2169/internalmedicine.49.3509 23 GanJ.HarperT