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Mitapivat-induced changes are not limited to reticulocytes, as suggested by the observed significant reduction of erythrophagocytosis (Figure 4B) and the direct effect of mitapivat on splenic macrophages resulting in a proresolving profile

1H-MRS studies in patients with MS also reported decreased Glu, Gln and/or Glx concentrations: Nantes et al (23) reported decreased Glu concentrations in the sensorimotor and parietal regions of the left cerebral hemisphere

Conclusion Both TMG (trimethylglycine) and glycine play essential yet distinct roles in maintaining long-term health and balance

10.1016/j.expneurol.2017.04.017 174 NicolsonR.Craven-ThussB.SmithJ