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doi: 10.1111/epi.13457 146

ROS are directly or indirectly associated with cytokine storm induction in SARS-CoV-2 infection, and ROS can activate NF-B and NLRP3 inflammasomes, thereby leading to the production of inflammatory cytokines and the development of acute respiratory distress syndrome and multiple organ dysfunction 62,63,64

Indeed, increasing interest is noted in further understanding the metabolic response of tumoral (and occasionally healthy) cell lines or tissues to drugs, both in vitro and in vivo