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Phase 1b study of the MDM2 inhibitor AMG 232 with or without trametinib in relapsed/refractory acute myeloid leukemia

Springer, New York, pp 155167 Paraskevopoulou V, Alissa M, Hage N, Falcone FH (2022b) Introduction of a hexalysine (6 K) tag can protect from N-terminal cleavage and increase yield of recombinant proteins expressed in the periplasm of E

However, this type of autophagy can also consume excessive metabolic proteins, such as hexokinase 2 (HK2), impairing normal cellular metabolism and triggering unexpected cell death (163)

A combination of ferroptosis inducers and HSF1 inhibitors resulted in tumor growth arrest in mice