inhibitor glutathione transferase S-transferase π: a potential role in antitumor therapy | DDDT Molecular dynamics-derived pharmacophores of Schistosoma

In NAFLD/MASLD, antioxidant approaches (vitamin E, glutathione) show modest biochemical and histological benefit mainly in earlier, non-cirrhotic stages, but robust outcome data in advanced disease are lacking ( Our finding that treatment duration did not influence outcomes across multiple analytic approaches (correlation analysis, stratified analysis, multivariate regression, machine learning) has important clinical implications

Tomasello G, Mazzola M, Leone A, Sinagra E, Zummo G, Farina F et al (2016) Nutrition, oxidative stress and intestinal dysbiosis-influence of diet on gut microbiota in inflammatory bowel diseases

Assay: GSH/GSSG in rat tissues and plasma

Activation induced by HCV and FFA leads to increased LAMP2A protein expression, resulting in the formation of a protein complex that includes HSC70, LAMP2A and IFNAR1 (207)