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General antioxidants, some of which exhibit ferroptosis inhibition in vitro , have also been evaluated clinically but with limited efficacy (Table 2)

Invasive nontyphoidal serotypes (iNTSs), which cause symptoms such as bacteremia and sepsis, are a significant concern (Uche et al., 2017)

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Here, we summarize the features, process, function, and mechanisms of ferroptosis, discuss its relevance with oxidative stress and cellular inflammation linking to cardiovascular disorders, raise the unsolved mysteries of ferroptosis, and provide new insights to consider the ferroptosis as the therapeutic target for the prevention and treatment of CVDs