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Pickart's pioneering work, along with subsequent studies published in journals including the Journal of Biological Chemistry and Dermatologic Surgery , has established GHK-Cu as a peptide with broad regenerative potential: Collagen Remodeling: GHK-Cu has been shown to stimulate synthesis of collagen types I, III, and V, along with elastin and decorin key components of the extracellular matrix essential for skin structure and wound repair

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These nontryptic methods have disadvantages at the spectral identification stage, in that all residues must be considered as potential cleavage sites