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The glutamate transport inhibitor dl-Threo--benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

While the expression of DNMT3B, DNMT3L, and TET1 is barely detectable in SCD erythroblasts, the expression of DNMT1, DNMT3A, TET2 or TET3 was not significantly changed at the mRNA or protein level after DMF treatment (Supplementary Fig

Published mechanistic studies exploring the role of dopamine signaling in NAFLD are limited, however, preclinical studies have illustrated that low, clinically relevant doses of AA medications can rapidly induce NAFLD/NASH in the absence of weight gain (Rostama et al., 2020) and these effects are associated with dramatic shifts in expression of the hepatic and cardiac proteomes (Rostama et al., 2020), consistent with altered signaling pathways, including those downstream of dopamine receptors

A notable subset of patients with MCAS or specific genetic variants (such as CBS gene mutations) have impaired transsulfuration pathways or severe sulfur sensitivities