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ern et al., 2018)

In this context, ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, plays a critical role in vascular injury and dysfunction ( Ferroptosis not only contributes to endothelial injury but also amplifies the inflammatory response in sepsis, creating a vicious cycle of vascular dysfunction and systemic inflammation ( In summary, ferroptosis plays a pivotal role in the pathophysiology of sepsis by contributing to endothelial injury, vascular dysfunction, and the amplification of systemic inflammation