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Sirt1 activation prevents high glucose-induced angiotensin converting enzyme 2 downregulation in renal tubular cells by regulating the TIMP3/ADAM17 pathway

10.1016/j.cell.2017.11.048 Cell 81 IshiiT.WarabiE.MannG

Yang X, Xu S, Qian Y, et al

This phenomenon is closely associated with a number of human disorders such as many degenerative diseases, including cardiovascular disease, diabetes, cancer and neurodegenerative disorders2,3 and with almost all liver pathologies.4-6 All these conditions appear to be mostly related to chronic oxidative stress